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Baked spicy Southern cheesy chicken spaghetti casserole in a dish, topped with melted golden cheese and diced tomatoes.

Spicy Southern Cheesy Chicken Spaghetti Casserole

A creamy, cheesy Southern casserole layered with tender chicken, spicy seasonings, and comforting pasta. Perfect for family dinners and weeknight comfort food cravings.
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Prep Time 15 minutes
Cook Time 30 minutes
Resting Time 5 minutes
Total Time 45 minutes
Servings: 8 bowls
Course: Main Course
Cuisine: Southern
Calories: 380
Ingredients Equipment Method Notes

Ingredients
  

Main Ingredients
  • 3-4 boneless, skinless chicken breasts about 1.5 lbs
  • 8 oz spaghetti cooked al dente
  • 2 cups shredded sharp cheddar cheese divided
  • 1 cup chopped fresh bell peppers red or yellow preferred
  • 1 can (10.5 oz) cream of chicken soup undiluted
  • 1 tsp paprika
  • 0.5 tsp cayenne pepper adjust to taste
  • 1 tsp garlic powder
  • 0.25 cup green onions sliced, for garnish

Equipment

  • Casserole Dish
  • Large Pot
  • Large Bowl
  • Skillet

Method
 

  1. Preheat your oven to 350°F (175°C). Grease a large casserole dish.
  2. Cook the chicken in a skillet over medium heat until golden and fully cooked (about 6–7 minutes per side). Shred and set aside.
  3. Boil spaghetti in salted water until al dente (8–10 minutes). Drain and let cool slightly.
  4. In a large bowl, mix shredded chicken, cooked spaghetti, cream of chicken soup, bell peppers, spices, and half of the cheddar cheese.
  5. Pour the mixture into the casserole dish. Top with remaining cheese.
  6. Bake uncovered for 25–30 minutes, or until bubbly and golden on top.
  7. Let it rest for 5 minutes. Garnish with green onions before serving.

Notes

Mix cheese off heat for best texture. Adjust cayenne for milder or hotter flavor. Don’t skip the resting period – it helps the casserole set.